Hydrochloric Acid → HCID 68574480、化合物
反応式
[CH3:1][CH:2]([CH3:22])[CH2:3][CH2:4][N:5]([CH2:12][C:13]1[O:14][C:15]2[CH:21]=[CH:20][CH:19]=[CH:18][C:16]=2[CH:17]=1)[CH:6]1[CH2:11][CH2:10][NH:9][CH2:8][CH2:7]1.[ClH:23].C(OCC)C>CO>[ClH:23].[ClH:23].[CH3:1][CH:2]([CH3:22])[CH2:3][CH2:4][N:5]([CH2:12][C:13]1[O:14][C:15]2[CH:21]=[CH:20][CH:19]=[CH:18][C:16]=2[CH:17]=1)[CH:6]1[CH2:7][CH2:8][NH:9][CH2:10][CH2:11]1参加物
5
実験手順
N-(3-Methylbutyl)-N-[(benzofuran-2-yl)methyl]piperidin-4-amine (0.09 g, 0.28 mmol) is dissolved in methanol (2 ml). 2.0 M HCl in diethyl ether (0.29 ml, 0.57 mmol) is added and the reaction stirred for 2 hours. The reaction is concentrated and the solid dried in a vacuum (60° C.) overnight to yield (0.77 g) of N-(3-methylbutyl)-N-[(benzofuran-2-yl)methyl]piperidin-4-amine dihydrochloride: mass spectrum (ion spray): m/z=301 (M+1).