Sodium Methoxide → 2-(3H-imidazo[4,5-b]pyridin-3-ylmethoxy)-ethanol

HRID 2112388ノート

反応式

HRID 2112388 の反応式
[N:1]1[C:9]2[C:4](=[N:5][CH:6]=[CH:7][CH:8]=2)[N:3]([CH2:10][O:11][CH2:12][CH2:13][O:14]C(=O)C)[CH:2]=1.C[O-].[Na+]>CO>[N:1]1[C:9]2[C:4](=[N:5][CH:6]=[CH:7][CH:8]=2)[N:3]([CH2:10][O:11][CH2:12][CH2:13][OH:14])[CH:2]=1

参加物

4

反応物 2

HCID 10942334Sodium MethoxideHCID 68879998acetic acid 2-(3H-imidazo[4,5-b]pyridin-3-ylmethoxy)-ethyl ester

生成物 1

HCID 144640472-(3H-imidazo[4,5-b]pyridin-3-ylmethoxy)-ethanol収率 99%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

0.79 g (3.36 mmol) acetic acid 2-(3H-imidazo[4,5-b]pyridin-3-ylmethoxy)-ethyl ester were dissolved in 10 ml methanol and 10 mg (1.85 mmol) sodium methoxide were added. The mixture was stirred at room temperature for 3 hours. The orange mixture was concentrated in vacuo to afford 0.64 g (99%) of crude product. MS (EI): 193.2, 163.2, 148.2, 133.2.

後処理

  1. concentrationThe orange mixture was concentrated in vacuo

出典と根拠

ORDレコード
ord-6a882374f2714fc8a71d2ed4c286d4ab
出典データセット
uspto-grants-2009_04
特許番号
US07524823B2

反応ノート

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