1-(Quinolin-4-yl)ethanol → 1-(Quinolin-4-yl)ethan-1-one
反応式
[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4]([CH:11]([OH:13])[CH3:12])=[CH:3][CH:2]=1>ClCCl.[O-2].[Mn+2]>[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4]([C:11](=[O:13])[CH3:12])=[CH:3][CH:2]=1参加物
4
実験手順
To the mixture of manganese oxide (8.69 g, 100 mmol, Aldrich) in dichloromethane (80 mL) was added 1-quinolin4-yl-ethanol (1.73 g, 10 mmol). The reaction mixture was refluxed for overnight and then cooled to room temperature. The solid was filtered out through Celite pad. The organic solution dried over anhydrous magnesium sulfate and concentrated via vacuo to give crude title compound as light yellow solid in 100% yield (1.71 g, 10.0 mmol).
後処理
- temperatureThe reaction mixture was refluxed for overnight
- filtrationThe solid was filtered out through Celite pad
- dry with materialThe organic solution dried over anhydrous magnesium sulfate
- concentrationconcentrated via vacuo
出典と根拠
- ORDレコード
- ord-9bd6cd05666a4e718f9834dcbefc00f3
- 出典データセット
- uspto-grants-2009_04
- 特許番号
- US07524873B2
反応ノート
読み込み中…