関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Cesium carbonate | HCID 10796 | — |
| 反応物 | Methyl bromoacetate | HCID 60984 | — |
| 反応物 | 2-Hydroxy-4-Methoxybenzaldehyde | HCID 69600 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 生成物 | Methyl 6-methoxybenzofuran-2-carboxylate | HCID 3016964 | — |
反応手順
A mixture of methyl bromoacetate (1.53 g, 10 mmol), 2-hydroxy-4-methoxybenzaldehyde (1.52 g, 10 mmol) and Cs2CO3 (6.5 g, 20 mmol) in DMF (100 mL) was stirred vigorously at 50° C. for 3 hrs and then at 150° C. for 5 min. The reaction was cooled, diluted with ethyl acetate and washed with water. The organic phase was dried and concentrated to give essentially pure 6-methoxy-benzofuran-2-carboxylic acid methyl ester as a solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07524882B2 |
|---|
| 出典データセット | uspto-grants-2009_04 |
|---|
| ORD ID | ord-bd952c834afe4e92806ea9bf045a73d9 |
|---|
| 出典メモ | uspto-grants-2009_04 |
|---|
