Hydrochloric Acid → Toluene-4-sulfonic acid piperidin-3-ylmethyl ester, hydrochloride
反応式
C(OC([N:8]1[CH2:13][CH2:12][CH2:11][CH:10]([CH2:14][O:15][S:16]([C:19]2[CH:24]=[CH:23][C:22]([CH3:25])=[CH:21][CH:20]=2)(=[O:18])=[O:17])[CH2:9]1)=O)(C)(C)C.[ClH:26]>O1CCOCC1>[ClH:26].[NH:8]1[CH2:13][CH2:12][CH2:11][CH:10]([CH2:14][O:15][S:16]([C:19]2[CH:20]=[CH:21][C:22]([CH3:25])=[CH:23][CH:24]=2)(=[O:18])=[O:17])[CH2:9]1参加物
4
実験手順
A mixture of 8.5 g (23 mmol) 3-(toluene-4-sulfonyloxymethyl)-piperidine-1-carboxylic acid tert-butyl ester and 28.7 mL (115 mmol) 4N HCl in dioxane in 30 mL dioxane was evaporated to dryness. This yielded 7.57 g (97%) of the title compound as viscous yellow oil which was used without further purification. MS(m/e): 270 (MH+).
後処理
- customwas evaporated to dryness
- customThis yielded 7.57 g (97%) of the title compound as viscous yellow oil which was used without further purification
出典と根拠
- ORDレコード
- ord-61d7ee3be3b744eca50cc8cfa7ac8a41
- 出典データセット
- uspto-grants-2008_10
- 特許番号
- US07432255B2
反応ノート
読み込み中…