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Chlorosuccinimide → 3-Chloro-1H-indole-5-carboxylic acid methyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Chlorosuccinimide | HCID 31398 | — |
| 反応物 | methyl 1H-indole-5-carboxylate | HCID 2737635 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | 3-Chloro-1H-indole-5-carboxylic acid methyl ester | HCID 21998728 | 62.6% |
反応手順
A mixture of 1.4 g (8 mmol) 1H-indole-5-carboxylic acid methyl ester and 1.28 g (9.6 mmol) N-chlorosuccinimid in 40 mL methanol was stirred at room temperature for 16 h. The mixture was evaporated to dryness and taken up in DCM washed with 1N NaHCO3 aq, dried with MgSO4, filtered and evaporated to dryness to yield 1.05 g (62%) of the title compound. MS(m/e): 210.1 (MH+).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07432255B2 |
| 出典データセット | uspto-grants-2008_10 |
| ORD ID | ord-3b5c17169e574e9a83ea3a80bfdc003e |
| 出典メモ | uspto-grants-2008_10 |