1-Methyl-3-aminopyrazole → 5-(6-ethanesulfonylpyridin-3-yloxy)-3-(2-methoxy-1-methyl-ethoxy)-N-(1-methyl-1H-pyrazol-3-yl)benzamide
反応式
CO[C:3](=[O:15])[C:4]1[CH:9]=[C:8]([OH:10])[CH:7]=[C:6]([O:11][CH2:12]OC)[CH:5]=1.BrC1[CH:18]=[CH:19][C:20]([S:23]([CH2:26][CH3:27])(=[O:25])=[O:24])=[N:21][CH:22]=1.O[C@H:29]([CH3:33])[CH2:30][O:31][CH3:32].[NH2:34][C:35]1[CH:39]=[CH:38][N:37]([CH3:40])[N:36]=1>>[CH2:26]([S:23]([C:20]1[N:21]=[CH:22][C:12]([O:11][C:6]2[CH:7]=[C:8]([O:10][CH:29]([CH3:33])[CH2:30][O:31][CH3:32])[CH:9]=[C:4]([CH:5]=2)[C:3]([NH:34][C:35]2[CH:39]=[CH:38][N:37]([CH3:40])[N:36]=2)=[O:15])=[CH:18][CH:19]=1)(=[O:24])=[O:25])[CH3:27]参加物
5
反応物 4
生成物 1
実験手順
The compound of Production Example 138 was obtained as a colorless amorphous substance using 5-hydroxy-3-methoxymethoxybenzoic acid methyl ester, 5-bromo-2-ethanesulfonylpyridine, (2R)-2-hydroxy-1-methoxypropane and 3-amino-1-methyl-1H-pyrazole, by the same method as in Production Example 117, a corresponding method, or a combination thereof with an ordinary method.