化工社化工社 化学情報印刷レポート · 研究参考用
Potassium Hydroxide → 1,3-Diphenyl-2-propyn-1-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Hydroxide | HCID 14797 | — |
| 反応物 | alpha-Bromochalcone | HCID 5383396 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | Propan-2-one--water (1/1) | HCID 18366337 | — |
| 生成物 | 1,3-Diphenyl-2-propyn-1-one | HCID 97637 | — |
反応手順
Potassium hydroxide (3.48 mmol), dissolved in water (0.87 M (4.0 ml)), is added over about 30 minutes to a refluxing solution of the alpha-bromochalcone (3.48 mmol) in 0.35 M of 1:1 water/acetone (5 ml each). After 20 minutes of further refluxing, the solution is cooled and diluted with water. The water is extracted with ether, which is dried with MgSO4 and evaporated. Chromatography on silica gel yielded 1,3-diphenylpropynone and its derivatives.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07432303B2 |
| 出典データセット | uspto-grants-2008_10 |
| ORD ID | ord-1acd341eaf5a4d21accda5b4441ab678 |
| 出典メモ | uspto-grants-2008_10 |