Ammonium Chloride → 4-(4-Amino-2-fluorophenoxy)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl ethylcarbamate

HRID 2114015ノート

反応式

HRID 2114015 の反応式
[CH2:1]([NH:3][C:4](=[O:27])[O:5][C:6]1[C:7]([CH3:26])=[C:8]2[N:13]([CH:14]=1)[N:12]=[CH:11][N:10]=[C:9]2[O:15][C:16]1[CH:21]=[CH:20][C:19]([N+:22]([O-])=O)=[CH:18][C:17]=1[F:25])[CH3:2].[NH4+].[Cl-]>C(O)C.[Zn]>[CH2:1]([NH:3][C:4](=[O:27])[O:5][C:6]1[C:7]([CH3:26])=[C:8]2[N:13]([CH:14]=1)[N:12]=[CH:11][N:10]=[C:9]2[O:15][C:16]1[CH:21]=[CH:20][C:19]([NH2:22])=[CH:18][C:17]=1[F:25])[CH3:2]

参加物

5

反応物 2

HCID 25517Ammonium ChlorideHCID 210816474-(2-Fluoro-4-nitrophenoxy)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl ethylcarbamate

生成物 1

HCID 210816674-(4-Amino-2-fluorophenoxy)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl ethylcarbamate収率 70.2%

試薬・触媒・溶媒 2

HCID 23994Zinc触媒HCID 702Ethanol溶媒

実験手順

To a solution of 4-(2-fluoro-4-nitrophenoxy)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl ethylcarbamate (12.5 mg, 0.033 mmol) in ethanol (2 mL) was added Zn (20 mg, 0.3 mmol) and NH4Cl (20 mg, 0.37 mmol). The reaction was stirred at room temperature for 1 h, filtered through Celite® and concentrated in vacuo to give the title compound (8 mg, 70%) as a white solid.

後処理

  1. filtrationfiltered through Celite®
  2. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-af2d4e0f40b04cc1960c3ec74d32152e
出典データセット
uspto-grants-2008_10
特許番号
US07432373B2

反応ノート

読み込み中…