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Triethylamine → 4-(2-Chlorobenzenesulfonyloxy)-7-[1-(tert-butoxycarbonyl)-5-(piperidinomethyl)indol-2-yl]isoindolinone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 2-Chlorobenzenesulfonyl chloride | HCID 76187 | — |
| 反応物 | 4-Hydroxy-7-[1-(tert-butoxycarbonyl)-5-(piperidinomethyl)indol-2-yl]isoindolinone | HCID 68493222 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | 4-(2-Chlorobenzenesulfonyloxy)-7-[1-(tert-butoxycarbonyl)-5-(piperidinomethyl)indol-2-yl]isoindolinone | HCID 86628248 | 75% |
反応手順
In a similar manner to Step 1 of Example 227, 4-hydroxy-7-[1-(tert-butoxycarbonyl)-5-(piperidinomethyl)indol-2-yl]isoindolinone (0.126 g, 0.274 mmol) was dissolved in acetonitrile (6.0 mL), and the solution was treated with triethylamine (0.0760 mL, 0.548 mmol) and 2-chlorobenzenesulfonyl chloride (0.0867 g, 0.411 mmol) to obtain 4-(2-chlorobenzenesulfonyloxy)-7-[1-(tert-butoxycarbonyl)-5-(piperidinomethyl)indol-2-yl]isoindolinone (0.130 g, yield 75%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07745641B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-b0fd96fdf13f4ff6aebe210f1f8bc51b |
| 出典メモ | uspto-grants-2010_06 |