Triethylamine → HCID 46941029、化合物

BOP (133 mg, 0.30 mmol) was added to a mixture containing (5-chloro-2-oxo-1,3-benzoxazol-3(2H)-yl)acetic acid (68 mg, 0.30 mmol), 2-(4-biphenylyl)-N-methyl-1-(1-pyrrolidinyl)-2-propanamine (74 mg, 0.25 mmol) and Et3N (0.042 ml, 0.30 mmol) in DMF (3 ml) and the resulting mixture was stirred at room temperature for 16 h. The crude reaction mixture was purified by preparative HPLC (Xterra PrepRP 30×100 mm, 45 mL/min, A: acetonitrile B: water, PH10, A: 50 to 90% over 12 min, UV detection at 214 nm) to give 17.5 mg (13.9%) as a white solid. MS(ES) m/e 504.4 [M+H]+

1. customThe crude reaction mixture
2. customwas purified by preparative HPLC (Xterra PrepRP 30×100 mm, 45 mL/min
3. waitA: acetonitrile B: water, PH10, A: 50 to 90% over 12 min
4. customUV detection at 214 nm) to give 17.5 mg (13.9%) as a white solid

ORDレコード

ord-ff17e4b88b7f407bb0bf94d6c6c725f7

出典データセット

uspto-grants-2008_10

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US07432258B2