3-Fluorobenzenesulfonyl Chloride → HCID 69317589、化合物

HRID 2114611ノート

反応式

HRID 2114611 の反応式
[CH:1]1([N:6]2[C:10]3[N:11]=[CH:12][N:13]=[C:14]([NH2:15])[C:9]=3[C:8]([C:16]3[NH:20][C:19]4[CH:21]=[C:22]([N+:25]([O-])=O)[CH:23]=[CH:24][C:18]=4[N:17]=3)=[CH:7]2)[CH2:5][CH2:4][CH2:3][CH2:2]1.[F:28][C:29]1[CH:30]=[C:31]([S:35](Cl)(=[O:37])=[O:36])[CH:32]=[CH:33][CH:34]=1>CS(C)=O>[NH2:15][C:14]1[C:9]2[C:8]([C:16]3[NH:20][C:19]4[CH:21]=[C:22]([NH:25][S:35]([C:31]5[CH:32]=[CH:33][CH:34]=[C:29]([F:28])[CH:30]=5)(=[O:37])=[O:36])[CH:23]=[CH:24][C:18]=4[N:17]=3)=[CH:7][N:6]([CH:1]3[CH2:5][CH2:4][CH2:3][CH2:2]3)[C:10]=2[N:11]=[CH:12][N:13]=1

参加物

4

反応物 2

HCID 27342583-Fluorobenzenesulfonyl ChlorideHCID 69320502HCID 69320502、化合物

生成物 1

HCID 69317589HCID 69317589、化合物

試薬・触媒・溶媒 1

HCID 679Dimethyl Sulfoxide溶媒

実験手順

The title compound was prepared by treatment of 5-(6-Amino-1H-benzoimidazol-2-yl)-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine (1E, 20 mg in 1.0 mL NMP) with 1.2 equiv. of 3-fluoro-benzenesulfonyl chloride (14.3 mg) at 80° C. for 2.5 h. LCMS was used to confirm product formation and the resulting reaction mixture was diluted with 1.0 mL DMSO and purified via preparative HPLC to furnish the desired product (M/Z 491.2, retention time 2.3 min. with analytical HPLC method 2).

後処理

  1. customthe resulting reaction mixture
  2. custompurified via preparative HPLC

出典と根拠

ORDレコード
ord-39018f5132b94d84a3ceb109ed094aa9
出典データセット
uspto-grants-2008_10
特許番号
US07435739B2

反応ノート

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