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2-Amino-4'-methoxyacetophenone → 2-(3-Chloro-thiophen-2-yl)-5-(4-methoxy-phenyl)-oxazole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Amino-4'-methoxyacetophenone | HCID 412889 | — |
| 反応物 | 3-Chlorothiophene-2-carbonyl chloride | HCID 2735824 | — |
| 生成物 | 2-(3-Chloro-thiophen-2-yl)-5-(4-methoxy-phenyl)-oxazole | HCID 22147907 | — |
反応手順
3-Choloro-thiophene-2-carboxylic acid-[2-(4-methoxy-phenyl)-2-oxo-ethyl]-amide: The title compound was prepared from 3-chloro-thiophene-2-carbonyl chloride and 2-amino-4′-methoxy acetophenone by a procedure similar to Example 93a as an orange solid. 1H NMR (DMSO-d6): 8.30 (s, NH), 8.02 (d, J=9.0 Hz, 1H), 7.89 (d, J=6.6 Hz, 2H), 7.20 (d, J=6.0 Hz, 2H), 7.10 (d, J=8.7 Hz, 1H), 4.80 (d, J=5.4 Hz, 2H), 3.86 (s, 3H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07435750B2 |
| 出典データセット | uspto-grants-2008_10 |
| ORD ID | ord-ebbe3cd86fdd4e9d9102fa312261485b |
| 出典メモ | uspto-grants-2008_10 |