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6-amino-1,3-benzoxazol-2(3H)-one → 2-Oxo-N-(2-oxo-2,3-dihydro-benzoxazol-6-yl)-2-(4-p-tolyloxy-piperidin-1-yl)-acetamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 6-amino-1,3-benzoxazol-2(3H)-one | HCID 826989 | — |
| 反応物 | Oxo-(4-p-tolyloxy-piperidin-1-yl)-acetic acid | HCID 69100252 | — |
| 生成物 | 2-Oxo-N-(2-oxo-2,3-dihydro-benzoxazol-6-yl)-2-(4-p-tolyloxy-piperidin-1-yl)-acetamide | HCID 10111285 | — |
反応手順
The title compound is prepared from oxo-(4-p-tolyloxy-piperidin-1-yl)-acetic acid (Example 26b) and 6-amino-3H-benzoxazol-2-one according to the method described in Example 2. The filtered crystals are purified by column chromatography using Kieselgel 60 (Merck) as adsorbent and toluene:methanol=4:1 as eluent. Melting Point: 203° C. (isopropanol)
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07435744B2 |
| 出典データセット | uspto-grants-2008_10 |
| ORD ID | ord-3bad3d901d504ceda55ec6688cc5b8b6 |
| 出典メモ | uspto-grants-2008_10 |