4-[(3,4-Difluorophenyl)methyl]piperidine → 2-[4-(3,4-Difluoro-benzyl)-piperidin-1-yl]-2-oxo-N-(2-oxo-2,3-dihydro-benzoxazol-6-yl)-acetamide
反応式
[F:1][C:2]1[CH:3]=[C:4]([CH:12]=[CH:13][C:14]=1[F:15])[CH2:5][CH:6]1[CH2:11][CH2:10][NH:9][CH2:8][CH2:7]1.[O:16]=[C:17]1[NH:21][C:20]2[CH:22]=[CH:23][C:24]([NH:26][C:27](=[O:31])[C:28](O)=[O:29])=[CH:25][C:19]=2[O:18]1>>[F:1][C:2]1[CH:3]=[C:4]([CH:12]=[CH:13][C:14]=1[F:15])[CH2:5][CH:6]1[CH2:7][CH2:8][N:9]([C:28](=[O:29])[C:27]([NH:26][C:24]2[CH:23]=[CH:22][C:20]3[NH:21][C:17](=[O:16])[O:18][C:19]=3[CH:25]=2)=[O:31])[CH2:10][CH2:11]1参加物
3
実験手順
The title compound is prepared from 4-(3,4-difluoro-benzyl)-piperidine [J. Org. Chem., 64, 3763. (1999)] and N-(2-oxo-2,3-dihydro-benzoxazol-6-yl)-oxalamic acid (Example 43e) according to the method described in Example 43f. The residue is purified by column chromatography using Kieselgel 60 (Merck) as adsorbent and toluene:methanol=4:1 as eluent. Melting Point: 233° C. (isopropanol)
後処理
- customThe residue is purified by column chromatography