Diethyl Ether → 2-(4-Phenoxy-methyl-piperidine-1-yl)-N-(3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-7-yl)-acetamide

反応式

Cl[CH2:2][C:3]([NH:5][C:6]1[CH:16]=[CH:15][C:9]2[NH:10][C:11](=[O:14])[CH2:12][O:13][C:8]=2[CH:7]=1)=[O:4].[O:17]([CH:24]1[CH2:29][CH2:28][N:27](C)[CH2:26][CH2:25]1)[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1.[CH2:31](OCC)C>>[O:17]([CH:24]1[CH2:25][CH2:26][N:27]([CH2:2][C:3]([NH:5][C:6]2[CH:16]=[CH:15][C:9]3[NH:10][C:11](=[O:14])[CH2:12][O:13][C:8]=3[CH:7]=2)=[O:4])[CH:28]([CH3:31])[CH2:29]1)[C:18]1[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=1

参加物

反応物 3

HCID 3283Diethyl Ether

HCID 187229981-Methyl-4-phenoxypiperidine

HCID 242982822-chloro-N-(3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-7-yl)-acetamide

生成物 1

HCID 691003012-(4-Phenoxy-methyl-piperidine-1-yl)-N-(3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-7-yl)-acetamide

実験手順

The title compound is prepared from 2-chloro-N-(3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-7-yl)-acetamide (Example 153a) and 4-phenoxy-methyl-piperidine according to the method described in Example 142b. Melting Point: 172-175° C. (diethylether)

出典と根拠

ORDレコード: ord-d8b95e48b120421fa6befa0ab730193d
出典データセット: uspto-grants-2008_10
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07435744B2

反応ノート

読み込み中…