6-amino-3,4-dihydroquinolin-2(1H)-one → 6-{2-[4-(4-Fluoro-benzyl)-piperidin-1-yl]-2-oxo-ethylamino}-3,4-dihydro-1H-quinolin-2-one

HRID 2115146

反応式

HRID 2115146 の反応式
[NH2:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[NH:8][C:7](=[O:12])[CH2:6][CH2:5]2.Cl[CH2:14][C:15]([N:17]1[CH2:22][CH2:21][CH:20]([CH2:23][C:24]2[CH:29]=[CH:28][C:27]([F:30])=[CH:26][CH:25]=2)[CH2:19][CH2:18]1)=[O:16]>C(O)C>[F:30][C:27]1[CH:28]=[CH:29][C:24]([CH2:23][CH:20]2[CH2:21][CH2:22][N:17]([C:15](=[O:16])[CH2:14][NH:1][C:2]3[CH:3]=[C:4]4[C:9](=[CH:10][CH:11]=3)[NH:8][C:7](=[O:12])[CH2:6][CH2:5]4)[CH2:18][CH2:19]2)=[CH:25][CH:26]=1

参加物

4

反応物 2

HCID 49127596-amino-3,4-dihydroquinolin-2(1H)-oneHCID 691000562-Chloro-1-[4-(4-fluoro-benzyl)-piperidin-1-yl]-ethanone

生成物 1

HCID 691006826-{2-[4-(4-Fluoro-benzyl)-piperidin-1-yl]-2-oxo-ethylamino}-3,4-dihydro-1H-quinolin-2-one

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

The title compound is prepared from 6-amino-3,4-dihydro-quinolin-2-one and 2-chloro-1-[4-(4-fluoro-benzyl)-piperidin-1-yl]-ethanone (Example 197a) according to the method described in Example 206. Melting Point: 197-200° C. (ethyl alcohol)

出典と根拠

ORDレコード
ord-cca28e7feefb476988880f7bfe4e83d5
出典データセット
uspto-grants-2008_10
特許番号
US07435744B2

関連ノート

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