化工社化工社 化学情報印刷レポート · 研究参考用
Triethylamine → 4-(3,5-Dimethylisoxazol-4-ylsulfonyloxy)-7-[1-(tert-butoxycarbonyl)-5-(piperidinomethyl)indol-2-yl]isoindolinone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 3,5-Dimethylisoxazole-4-sulfonyl chloride | HCID 2736319 | — |
| 反応物 | 4-Hydroxy-7-[1-(tert-butoxycarbonyl)-5-(piperidinomethyl)indol-2-yl]isoindolinone | HCID 68493222 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | 4-(3,5-Dimethylisoxazol-4-ylsulfonyloxy)-7-[1-(tert-butoxycarbonyl)-5-(piperidinomethyl)indol-2-yl]isoindolinone | HCID 86628259 | 23.5% |
反応手順
In a similar manner to Step 1 of Example 233, 4-hydroxy-7-[1-(tert-butoxycarbonyl)-5-(piperidinomethyl)indol-2-yl]isoindolinone (0.0291 g, 0.0630 mmol) was dissolved in acetonitrile (0.650 mL), and the solution was treated with triethylamine (0.0540 mL, 0.390 mmol) and 3,5-dimethylisoxazol-4-sulfonyl chloride (0.0382 g, 0.195 mmol) to obtain 4-(3,5-dimethylisoxazol-4-ylsulfonyloxy)-7-[1-(tert-butoxycarbonyl)-5-(piperidinomethyl)indol-2-yl]isoindolinone (0.0092 g, yield 23%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07745641B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-a80d0a8cd9164f43ba49a86a1d0ed048 |
| 出典メモ | uspto-grants-2010_06 |