Hydrochloric Acid → 5-Amino-1-methyl-1,2-dihydropyridin-2-one hydrochloride
反応式
[CH3:1][N:2]1[C:7](=[O:8])[CH:6]=[CH:5][C:4]([NH:9]C(=O)OC(C)(C)C)=[CH:3]1.[ClH:17]>O1CCOCC1>[ClH:17].[NH2:9][C:4]1[CH:5]=[CH:6][C:7](=[O:8])[N:2]([CH3:1])[CH:3]=1参加物
4
反応条件
- 温度
- 70 °C
実験手順
To a stirred solution of tert-butyl 1-methyl-6-oxo-1,6-dihydropyridin-3-ylcarbamate (1.20 g, 5.35 mmol) in dioxane (15 mL) at RT was added HCl (4M in dioxane, 5.35 mL, 21.4 mmol). The reaction mixture was heated at 70° C. for 9 h, cooled to RT and filtered to give the title compound.
後処理
- temperaturecooled to RT
- filtrationfiltered
出典と根拠
- ORDレコード
- ord-c5e7b0d880e8466b8942b38753555c95
- 出典データセット
- uspto-grants-2008_10
- 特許番号
- US07435823B2
反応ノート
読み込み中…