Boron tribromide → 4'-Chloro-2'-methyl[1,1'-biphenyl]-2-ol
反応式
C[O:2][C:3]1[C:4]([C:9]2[CH:14]=[CH:13][C:12]([Cl:15])=[CH:11][C:10]=2[CH3:16])=[CH:5][CH:6]=[CH:7][CH:8]=1.B(Br)(Br)Br>>[Cl:15][C:12]1[CH:13]=[CH:14][C:9]([C:4]2[C:3]([OH:2])=[CH:8][CH:7]=[CH:6][CH:5]=2)=[C:10]([CH3:16])[CH:11]=1参加物
3
実験手順
Treatment of 2-bromo-5-chlorotoluene (5.0 g, 24.33 mmol) with 2-methoxybenzeneboronic acid (4.8 g, 31.63 mmol), dichlorobis(tri-o-tolylphosphine)-palladium(II) (0.478 g, 0.608 mmol), and potassium carbonate (8.41 g, 60.83 mmol) generally according to the procedure described for Intermediate 37 provided 5.05 g (89%) of 4′-chloro-2′-methyl-1,1′-biphenyl-2-yl methyl ether. Treatment of 4′-chloro-2′-methyl-1,1′-biphenyl-2-yl methyl ether (5.05 g, 21.48 mmol) with boron tribromide (5.37 g, 1.0 M in dichloromethane) generally according to the procedure described for Intermediate 163 provided 4.58 g (97%) of 4′-chloro-2′-methyl-1,1′-biphenyl-2-ol as a yellow oil. Anal. calcd. for C13H11ClO: C, 71.4; H, 5.07. Found: C, 71.03; H, 4.84.
出典と根拠
- ORDレコード
- ord-aeb53d91919843a9b186c8b961f2d52e
- 出典データセット
- uspto-grants-2008_10
- 特許番号
- US07435837B2
反応ノート
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