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Triethylamine → HCID 86628268、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 3,5-Dichlorobenzenesulfonyl chloride | HCID 522388 | — |
| 反応物 | 4-Hydroxy-7-[1-(tert-butoxycarbonyl)-5-(piperidinomethyl)indol-2-yl]isoindolinone | HCID 68493222 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | HCID 86628268 | HCID 86628268 | 44% |
反応手順
In a similar manner to Step 1 of Example 233, 4-hydroxy-7-[1-(tert-butoxycarbonyl)-5-(piperidinomethyl)indol-2-yl]isoindolinone (0.0332 g, 0.0719 mmol) was dissolved in acetonitrile (0.650 mL), and the solution was treated with triethylamine (0.0600 mL, 0.432 mmol) and 3,5-dichlorobenzenesulfonylchloride (0.0530 g, 0.216 mmol) to obtain 4-(3,5-dichlorobenzenesulfonyloxy)-7-[1-(tert-butoxycarbonyl)-5-(piperidinomethyl)indol-2-yl]isoindolinone (0.0212 g, yield 44%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07745641B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-3364c36a8cfa4aaf8e22c4e9749191a3 |
| 出典メモ | uspto-grants-2010_06 |