Sodium methanethiolate → N-(4-Chlorophenyl)-9-ethyl-2-(methylthio)-9H-purin-6-amine
反応式
Cl[C:2]1[N:10]=[C:9]2[C:5]([N:6]=[CH:7][N:8]2[CH2:11][CH3:12])=[C:4]([NH:13][C:14]2[CH:19]=[CH:18][C:17]([Cl:20])=[CH:16][CH:15]=2)[N:3]=1.[CH3:21][S-:22].[Na+]>CS(C)=O>[Cl:20][C:17]1[CH:18]=[CH:19][C:14]([NH:13][C:4]2[N:3]=[C:2]([S:22][CH3:21])[N:10]=[C:9]3[C:5]=2[N:6]=[CH:7][N:8]3[CH2:11][CH3:12])=[CH:15][CH:16]=1参加物
4
反応条件
- 温度
- 110 °C
実験手順
A mixture of the product from step (ii) (0.6 g) and sodium thiomethoxide (0.45 g) in dimethylsulphoxide (15 ml) was heated at 110° C. for 4 h. The mixture was partitioned between ethyl acetate and water, the organics washed with water, dried (MgSO4) and evaporated under reduced pressure. Yield 0.45 g