Hydrochloric Acid → (4-Methoxycarbonylphenyl)-(3-hydroxypyridin-4-yl)-methanol hydrochloride

HRID 2116489ノート

反応式

HRID 2116489 の反応式
[CH3:1][O:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([CH:11]([C:13]2[CH:18]=[CH:17][N:16]=[CH:15][C:14]=2[O:19]COC)[OH:12])=[CH:7][CH:6]=1)=[O:4].[ClH:23]>CO>[ClH:23].[CH3:1][O:2][C:3]([C:5]1[CH:6]=[CH:7][C:8]([CH:11]([C:13]2[CH:18]=[CH:17][N:16]=[CH:15][C:14]=2[OH:19])[OH:12])=[CH:9][CH:10]=1)=[O:4]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 69220240(4-Methoxycarbonylphenyl)-[3-(methoxymethoxy)pyridin-4-yl]-methanol

生成物 1

HCID 23103650(4-Methoxycarbonylphenyl)-(3-hydroxypyridin-4-yl)-methanol hydrochloride収率 81%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

Next, a mixture of (4-methoxycarbonylphenyl)-[3-(methoxymethoxy)pyridin-4-yl]-methanol (2.06 g, 6.79 mmol), methanol (35 mL) and concentrated hydrochloric acid (4.4 mL) was heated under reflux for 20 minutes. After cooling to room temperature, the reaction mixture was concentrated. Methanol and ethyl acetate were added to the residue and the resulting precipitate was filtered to give (4-methoxycarbonylphenyl)-(3-hydroxypyridin-4-yl)-methanol hydrochloride (1.87 g, 81%).

後処理

  1. temperaturewas heated
  2. temperatureunder reflux for 20 minutes
  3. concentrationthe reaction mixture was concentrated
  4. additionMethanol and ethyl acetate were added to the residue
  5. filtrationthe resulting precipitate was filtered

出典と根拠

ORDレコード
ord-7ac00c7dfd4f4115be1636b672730a99
出典データセット
uspto-grants-2008_10
特許番号
US07439232B2

反応ノート

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