Ngx-267 → (R)-2-Ethyl-8-methyl-1-thia-4,8-diaza-spiro[4.5]decan-3-one

HRID 2116583ノート

反応式

HRID 2116583 の反応式
[CH2:1]([C@H:3]1[C:7](=[O:8])[NH:6][C:5]2([CH2:13][CH2:12][N:11]([CH3:14])[CH2:10][CH2:9]2)[S:4]1)[CH3:2]>C1CCCCC1>[CH2:1]([C@@H:3]1[C:7](=[O:8])[NH:6][C:5]2([CH2:13][CH2:12][N:11]([CH3:14])[CH2:10][CH2:9]2)[S:4]1)[CH3:2]

参加物

3

反応物 1

HCID 10013505Ngx-267

生成物 1

HCID 11694209(R)-2-Ethyl-8-methyl-1-thia-4,8-diaza-spiro[4.5]decan-3-one

試薬・触媒・溶媒 1

HCID 8078Cyclohexane溶媒

実験手順

The obtained (R)-2-mercaptobutyric acid was purified by distillation and then reacted with ammonium acetate and 1-methyl-4-piperidone in boiling cyclohexane. The crude reaction mixture was analyzed by GC on a chiral column and found to contain AF267A accompanied by a small (2-3%) amount of AF267B.

後処理

  1. distillationThe obtained (R)-2-mercaptobutyric acid was purified by distillation
  2. customreacted with ammonium acetate and 1-methyl-4-piperidone
  3. customThe crude reaction mixture

出典と根拠

ORDレコード
ord-5d9a2257d1374c33bfcfb25fc22d07d0
出典データセット
uspto-grants-2008_10
特許番号
US07439251B2

反応ノート

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