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Potassium Carbonate → 4-(4-fluorophenyl)-7-{[5-(1-hydroxy-1-methylpropyl)-1,3-thiazol-2-yl]thio}-2H-chromen-2-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 7-Bromo-4-(4-fluorophenyl)-chromen-2-one | HCID 23370243 | — |
| 反応物 | HCID 178450294 | HCID 178450294 | — |
| 溶媒 | N-methyl-2-pyrrolidone | HCID 13387 | — |
| 生成物 | 4-(4-fluorophenyl)-7-{[5-(1-hydroxy-1-methylpropyl)-1,3-thiazol-2-yl]thio}-2H-chromen-2-one | HCID 59814854 | — |
反応手順
Employing the procedure described in Example 1, Step 3, using 7-bromo-4-(4-fluorophenyl)-2H-chromen-2-one, 2-(2-mercapto-1,3-thiazole-5-yl)butan-2-ol and K2CO3 in NMP, the title compound was obtained. 1H NMR (400 MHz, acetone-d6): δ 7.72 (s, 1H), 7.63-7.68 (m, 2H), 7.51 (d, 1H), 7.43 (d, 1H), 7.33-7.41 (m, 3H), 6.38 (s, 1H), 1.93-1.80 (m, 2H), 1.61 (s, 3H), 0.90 (t, 3H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07439260B2 |
| 出典データセット | uspto-grants-2008_10 |
| ORD ID | ord-b6fe53f822ea4d28a1277ff6342d4587 |
| 出典メモ | uspto-grants-2008_10 |