化工社化工社 化学情報印刷レポート · 研究参考用
Water → Tolterodine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Sodium Carbonate | HCID 10340 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | (R)-2-(3-(Diisopropylamino)-1-phenylpropyl)-4-methylphenol 2,3-dihydroxysuccinate | HCID 9847786 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | Tolterodine | HCID 443879 | — |
反応手順
Tolterodine tartrate (2.1 g) is mixed with water (45 ml) and toluene (2.5 ml). Sodium carbonate (800 mg) is added to the slurry. Sodium hydroxide (2.0 N, 1.5 ml) is added. The mixture is extracted three times with toluene (3 ml), saving the organic phase. Anhydrous potassium carbonate is added to the organic phase dissolve the tolterodine tartate, giving the title compound in solution.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07439397B2 |
| 出典データセット | uspto-grants-2008_10 |
| ORD ID | ord-00454ea3d27d4de6ae950ba71adb20fc |
| 出典メモ | uspto-grants-2008_10 |