Hydrochloric Acid → Atomoxetine Hydrochloride
反応式
[ClH:1].[CH3:2][C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][C:8]=1[O:9][C@@H:10]([C:15]1[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=1)[CH2:11][CH2:12][NH:13][CH3:14]>>[CH3:2][C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][C:8]=1[O:9][C@@H:10]([C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)[CH2:11][CH2:12][NH:13][CH3:14].[ClH:1]参加物
3
実験手順
Under stirring, and maintaining temperature between 18° C. and 20° C. by means of water bath cooling, 3.27 g (0.03263 mol) of aqueous hydrogen chloride (36.4%) was dropped on 58.2 g (0.02967 mol) of the atomoxetine base solution obtained above. Atomoxetine hydrochloride then crystallized out. The obtained suspension was stirred at about 20° C. for one hour, the solid is collected by filtration, and washed twice with 6 ml of n-butyl acetate. The solid was collected and dried for 18 hours at 45° C. under vacuum.
後処理
- temperaturemaintaining temperature between 18° C. and 20° C. by means of water bath
- temperaturecooling
- customobtained above
- customAtomoxetine hydrochloride then crystallized out
- stirringThe obtained suspension was stirred at about 20° C. for one hour