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HRID 2116909作成日：2026年10月26日

2-Chloro-3-(trifluoromethyl)pyridine → 2-(4-(4,5-Bis-(4-(trifluoromethyl)phenyl)-1H-imidazol-2-yl)-5,6-dihydropyridin-1(2H)-yl)-3-(trifluoromethyl)pyridine

https://huagongshe.com/reaction/2116909

反応式

関与物質

役割名称HCID仕込み量
反応物2-Chloro-3-(trifluoromethyl)pyridineHCID 589833—
反応物4-[4,5-Bis-(4-trifluoromethyl-phenyl)-1H-imidazol-2-yl]-1,2,3,6-tetrahydropyridineHCID 58625818—
生成物2-(4-(4,5-Bis-(4-(trifluoromethyl)phenyl)-1H-imidazol-2-yl)-5,6-dihydropyridin-1(2H)-yl)-3-(trifluoromethyl)pyridineHCID 11664273—

反応手順

4-[4,5-Bis-(4-trifluoromethyl-phenyl)-1H-imidazol-2-yl]-1,2,3,6-tetrahydropyridine from step (b) above reacted with 2-chloro-3-trifluoromethyl-pyridine (352 mg, 1.95 mmol, TCI America) under the condition of Example 22(d) to give the title compound as a light-yellow solid. MS (ESI, positive ion) m/z: 583 (M+1).

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US07439360B2
出典データセットuspto-grants-2008_10
ORD IDord-7a47e49fe73340bfa085bb8b3b2f028d
出典メモuspto-grants-2008_10