4-(4-Amino-3-fluorophenyl)morpholin-3-one → 5-chloro-thiophene-2-carboxylic acid {(1RS,2SR,4SR)-4-[2-fluoro-4-(3-oxo-morpholin-4-yl)-phenylcarbamoyl]-2-hydroxy-cyclopentylmethyl}-amide

反応式

[CH3:1][O:2][C:3](=[O:4])[CH:5]1[CH2:6][CH:7]([CH2:11][NH:12][C:13](=[O:14])[c:15]2[s:16][c:17]([Cl:20])[cH:18][cH:19]2)[CH:8]([OH:10])[CH2:9]1.[NH2:21][c:22]1[c:23]([F:35])[cH:24][c:25]([N:28]2[C:29](=[O:34])[CH2:30][O:31][CH2:32][CH2:33]2)[cH:26][cH:27]1>>[C:3](=[O:4])([CH:5]1[CH2:6][CH:7]([CH2:11][NH:12][C:13](=[O:14])[c:15]2[s:16][c:17]([Cl:20])[cH:18][cH:19]2)[CH:8]([OH:10])[CH2:9]1)[NH:21][c:22]1[c:23]([F:35])[cH:24][c:25]([N:28]2[C:29](=[O:34])[CH2:30][O:31][CH2:32][CH2:33]2)[cH:26][cH:27]1

参加物

反応物 2

HCID 534177984-(4-Amino-3-fluorophenyl)morpholin-3-one

HCID 68687973(1SR,3RS,4SR)-3-{[(5-chloro-thiophene-2-carbonyl)-amino]-methyl}-4-hydroxy-cyclopentanecarboxylic acid methyl ester

生成物 1

HCID 732308785-chloro-thiophene-2-carboxylic acid {(1RS,2SR,4SR)-4-[2-fluoro-4-(3-oxo-morpholin-4-yl)-phenylcarbamoyl]-2-hydroxy-cyclopentylmethyl}-amide

出典と根拠

ORDレコード: ord-d85e476210de4c5284b1e01cae10afae
出典データセット: Training data from https://doi.org/10.1039/C8SC04228D (6/10)
DOI: 10.1039/C8SC04228D

反応ノート

読み込み中…