4-(Quinolin-2-ylmethoxy)-butan-1-ol → {4-Chloro-2-methyl-6-[4-(quinolin-2-ylmethoxy)-butoxymethyl]-phenoxy}-acetonitrile

反応式

[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[CH2:11][O:12][CH2:13][CH2:14][CH2:15][CH2:16][OH:17].Br[CH2:19][C:20]1[CH:29]=[C:28]([Cl:30])[CH:27]=[C:26]([CH3:31])[C:21]=1[O:22][CH2:23][C:24]#[N:25]>>[Cl:30][C:28]1[CH:27]=[C:26]([CH2:31][O:17][CH2:16][CH2:15][CH2:14][CH2:13][O:12][CH2:11][C:2]2[CH:3]=[CH:4][C:5]3[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=3)[N:1]=2)[C:21]([O:22][CH2:23][C:24]#[N:25])=[C:20]([CH3:19])[CH:29]=1

参加物

反応物 2

HCID 180080564-(Quinolin-2-ylmethoxy)-butan-1-ol

HCID 22241394(2-Bromomethyl-4-chloro-6-methyl-phenoxy)-acetonitrile

生成物 1

HCID 18008041{4-Chloro-2-methyl-6-[4-(quinolin-2-ylmethoxy)-butoxymethyl]-phenoxy}-acetonitrile

実験手順

MS (ESI) 424 (M+H)+. Prepared from 4-(quinolin-2-ylmethoxy)-butan-1-ol (EXAMPLE-34b) and (2-bromomethyl-4-chloro-6-methyl-phenoxy)-acetonitrile.

出典と根拠

ORDレコード: ord-5b3b3feb6f174f1198110cd6f023bf90
出典データセット: uspto-grants-2008_10
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: USRE040558E1

反応ノート

読み込み中…