2-Amino-6-chlorobenzaldehyde → (+/-)-1-(2-Amino-6-chlorophenyl)-2-(3,4-difluorophenyl)ethanol
反応式
[NH2:1][C:2]1[CH:9]=[CH:8][CH:7]=[C:6]([Cl:10])[C:3]=1[CH:4]=[O:5].[F:11][C:12]1[CH:13]=[C:14]([CH:18]=[CH:19][C:20]=1[F:21])[CH2:15][Mg]Br>C(OCC)(=O)C>[NH2:1][C:2]1[CH:9]=[CH:8][CH:7]=[C:6]([Cl:10])[C:3]=1[CH:4]([OH:5])[CH2:15][C:14]1[CH:18]=[CH:19][C:20]([F:21])=[C:12]([F:11])[CH:13]=1参加物
4
実験手順
This compound was prepared using General Method 1 (EXAMPLE 1) from 2-amino-6-chlorobenzaldehyde (0.30 g, 1.9 mmol) and 3,4-difluorobenzylmagnesium bromide (generated from 3,4-difluorobenzyl bromide and magnesium in ether, 3.9 mmol, 2 equiv) to afford 0.28 g (57%) of (±)-1-(2-amino-6-chlorophenyl)-2-(3,4-difluorophenyl)ethanol after flash chromatography (4:1 hexanes:ethyl acetate).
後処理
- customThis compound was prepared
出典と根拠
- ORDレコード
- ord-c187a39e288e4920babc609538a053d3
- 出典データセット
- uspto-grants-2008_10
- 特許番号
- US07442696B2
反応ノート
読み込み中…