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HRID 2117400作成日：2026年10月27日

2-Isopropoxy-5-methylsulfonylbenzoic acid → (2-Isopropoxy-5-methanesulfonyl-phenyl)-(2-trifluoromethyl-7,8-dihydro-5H-[1,6]naphthyridin-6-yl)-methanone

https://huagongshe.com/reaction/2117400

反応式

関与物質

役割名称HCID仕込み量
反応物2-Isopropoxy-5-methylsulfonylbenzoic acidHCID 21100237—
反応物2-(Trifluoromethyl)-5,6,7,8-tetrahydro-1,6-naphthyridine hydrochlorideHCID 57445256—
生成物(2-Isopropoxy-5-methanesulfonyl-phenyl)-(2-trifluoromethyl-7,8-dihydro-5H-[1,6]naphthyridin-6-yl)-methanoneHCID 57445255—

反応手順

Prepared in analogy to example 1.1 from 2-trifluoromethyl-5,6,7,8-tetrahydro-[1,6]naphthyridine hydrochloride (CA [741736-98-1]; WO2004069162) and 2-isopropoxy-5-methanesulfonyl-benzoic acid (Example 2.1). MS (m/e): 443.5 (M+H+).

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US07442710B2
出典データセットuspto-grants-2008_10
ORD IDord-6f91acfb10e6475ca8a3730741327125
出典メモuspto-grants-2008_10