5-(4-Formylphenyl)pyrimidine → 3-{3-[(4-Pyrimidin-5-yl-benzylamino)-methyl]-phenyl}propionic acid methyl ester

HRID 2117505

反応式

HRID 2117505 の反応式
Cl.[CH3:2][O:3][C:4](=[O:15])[CH2:5][CH2:6][C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([CH2:13][NH2:14])[CH:8]=1.[N:16]1[CH:21]=[C:20]([C:22]2[CH:29]=[CH:28][C:25]([CH:26]=O)=[CH:24][CH:23]=2)[CH:19]=[N:18][CH:17]=1>CO>[CH3:2][O:3][C:4](=[O:15])[CH2:5][CH2:6][C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([CH2:13][NH:14][CH2:26][C:25]2[CH:24]=[CH:23][C:22]([C:20]3[CH:19]=[N:18][CH:17]=[N:16][CH:21]=3)=[CH:29][CH:28]=2)[CH:8]=1

参加物

4

反応物 2

HCID 38612125-(4-Formylphenyl)pyrimidineHCID 22282736Methyl 3-(3-(aminomethyl)phenyl)propanoate hydrochloride

生成物 1

HCID 542194583-{3-[(4-Pyrimidin-5-yl-benzylamino)-methyl]-phenyl}propionic acid methyl ester

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

The title compound of Step A was prepared from 3-(3-aminomethyl-phenyl)-propionic acid methyl ester hydrochloride salt, of Preparation 44, and 4-pyrimidin- 5-yl-benzaldehyde, of Preparation 26, using the method described in Example 1, Step A except the mine was formed in MeOH at reflux over 2 h. 1H NMR (400 MHz, CDCl3) δ 9.19 (s, 1H), 8.92 (s, 2H), 7.55 (m, 4H), 7.25 (m, 3H), 7.11 (d, 1H), 3.87 (s, 2H), 3.81 (s, 2H), 3.66 (s, 3H), 2.95 (t, 2H), 2.63 (t, 2H); MS 362 (M+1).

後処理

  1. temperatureat reflux over 2 h

出典と根拠

ORDレコード
ord-5137897c6d2947ca83dd65a5f649a173
出典データセット
uspto-grants-2008_10
特許番号
US07442702B2

関連ノート

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