Hydroxylamine → HCID 72819808、化合物
反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([C:11]2[CH:16]=[CH:15][N:14]=[CH:13][CH:12]=2)=[O:10])=[CH:4][CH:3]=1.C([O-])(=O)C.[Na+].[NH2:22][OH:23]>CO>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[N:22][OH:23])[C:9]([C:11]2[CH:16]=[CH:15][N:14]=[CH:13][CH:12]=2)=[O:10])=[CH:4][CH:3]=1参加物
5
実験手順
2-(4-Fluorophenyl)-1-(4-pyridinyl)ethanone (0.1 mol/25.2 g) was suspended in 330 ml of methanol. After addition of sodium acetate (0.44 mol/36.1 g) and hydroxylamine*HCl (0.32 mol/22.0 g), the reaction mixture was heated under reflux with stirring for 1 h. On cooling in an ice bath, the title compound was obtained as a white precipitate. The precipitate was filtered off, washed with H2O and dried over P2O5 under reduced pressure. Yield: 14.3 g (62%)
後処理
- temperaturethe reaction mixture was heated
- temperatureunder reflux
- temperatureOn cooling in an ice bath
出典と根拠
- ORDレコード
- ord-cfa0554f115d42c9a4bc7d94ecdab9ab
- 出典データセット
- uspto-grants-2008_10
- 特許番号
- US07442713B2
反応ノート
読み込み中…