2-Propanone, 1-(acetyloxy)-3-chloro- → (2-Aminothiazol-4-yl)methyl acetate hydrochloride
反応式
[C:1]([O:4][CH2:5][C:6](=O)[CH2:7][Cl:8])(=[O:3])[CH3:2].[NH2:10][C:11]([NH2:13])=[S:12]>C(O)C>[ClH:8].[C:1]([O:4][CH2:5][C:6]1[N:10]=[C:11]([NH2:13])[S:12][CH:7]=1)(=[O:3])[CH3:2]参加物
4
実験手順
A mixture of 3-chloro-2-oxopropyl acetate (5 g) and thiourea (2.5 g) in ethanol (25 ml) was refluxed for 4-hours. The reaction mixture was cooled to ambient temperature and the resulting crystalline precipitate was collected by filtration and washed with ethanol (20 ml) to give (2-amino-1,3-thiazol-4-yl)methyl acetate hydrochloride (3.5 g) as white crystals.
後処理
- temperaturewas refluxed for 4-hours
- filtrationthe resulting crystalline precipitate was collected by filtration
- washwashed with ethanol (20 ml)
出典と根拠
- ORDレコード
- ord-3424f2996be1449aa497ec116d632b5b
- 出典データセット
- uspto-grants-2008_10
- 特許番号
- US07442715B2
反応ノート
読み込み中…