N-[2-[4-(2-CHLOROACETYL)PHENYL]ETHYL]ACETAMIDE → HCID 21914684、化合物

HRID 2117859ノート

反応式

HRID 2117859 の反応式
[Cl:1][CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([CH2:11][CH2:12][NH:13][C:14](=[O:16])[CH3:15])=[CH:7][CH:6]=1)=O.[NH2:17][C:18]([NH2:20])=[S:19]>C(O)C>[ClH:1].[NH2:20][C:18]1[S:19][CH:2]=[C:3]([C:5]2[CH:10]=[CH:9][C:8]([CH2:11][CH2:12][NH:13][C:14](=[O:16])[CH3:15])=[CH:7][CH:6]=2)[N:17]=1

参加物

4

反応物 2

HCID 2468242N-[2-[4-(2-CHLOROACETYL)PHENYL]ETHYL]ACETAMIDEHCID 2723790Thiourea

生成物 1

HCID 21914684HCID 21914684、化合物収率 90.4%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

N-{2-[4-(2-Chloroacetyl)phenyl]ethyl}acetamide (1.06 g) and thiourea (505 mg) were dissolved in ethanol (20 mL). The mixture was refluxed for 1 hour and allowed to cool to room temperature. The white solid was collected with filtration and washed with ethanol to give N-{2-[4-(2-amino-1,3-thiazol-4-yl)phenyl]ethyl}acetamide hydrochloride (1.19 g, 90.4%).

後処理

  1. temperatureThe mixture was refluxed for 1 hour
  2. filtrationThe white solid was collected with filtration
  3. washwashed with ethanol

出典と根拠

ORDレコード
ord-f7472cd2f1fb4d349648fad5453e146f
出典データセット
uspto-grants-2008_10
特許番号
US07442715B2

反応ノート

読み込み中…