Acetic Acid → HCID 21063991、化合物

HRID 2118013ノート

反応式

HRID 2118013 の反応式
[Cl:1]Cl.[OH:3][CH2:4][CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[NH:12][C:13](=[O:15])[CH3:14].[C:16]([OH:19])(=O)[CH3:17]>>[C:13]([NH:12][C:7]1[CH:8]=[CH:9][C:10]([Cl:1])=[CH:11][C:6]=1[CH2:5][CH2:4][O:3][C:16](=[O:19])[CH3:17])(=[O:15])[CH3:14]

参加物

4

反応物 3

HCID 176Acetic Acid2 回HCID 24526ChlorineHCID 50350Acetanilide, 2'-(2-hydroxyethyl)-

生成物 1

HCID 21063991HCID 21063991、化合物

実験手順

A solution of chlorine in glacial acetic acid (0.98M, 30 ml) was added dropwise to a solution of N-[2-(2-Hydroxy-ethyl)-phenyl]-acetamide (5.0 g, 27.9 mmol)(see reference Biochemistry 1979, 18(5), 860) in glacial acetic acid (50 ml) and the mixture was stirred at room temperature for 20 hours. The glacial acetic acid was removed under reduced pressure. The resulting oil was triturated with diethyl ether to give the title compound (3.3 g) as a pale yellow solid after filtration.

後処理

  1. customThe glacial acetic acid was removed under reduced pressure
  2. customThe resulting oil was triturated with diethyl ether

出典と根拠

ORDレコード
ord-39ef470c62b04361941c765c217e15ac
出典データセット
uspto-grants-2008_10
特許番号
US07442795B2

反応ノート

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