Hydrochloric Acid → Fasudil Hydrochloride

HRID 2118500

反応式

HRID 2118500 の反応式
[CH:1]1[C:10]2[CH:9]=[CH:8][CH:7]=[C:6]([S:11]([N:14]3[CH2:20][CH2:19][CH2:18][NH:17][CH2:16][CH2:15]3)(=[O:13])=[O:12])[C:5]=2[CH:4]=[CH:3][N:2]=1.[ClH:21]>CO>[ClH:21].[CH:1]1[C:10]2[CH:9]=[CH:8][CH:7]=[C:6]([S:11]([N:14]3[CH2:20][CH2:19][CH2:18][NH:17][CH2:16][CH2:15]3)(=[O:12])=[O:13])[C:5]=2[CH:4]=[CH:3][N:2]=1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 3547Fasudil

生成物 1

HCID 163751Fasudil Hydrochloride

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

5 g of 1-(5-isoquinolinesulfonyl)homopiperazine (Compound(1)) as prepared in substantially the same manner as in Example 3 was dissolved in 40 ml of methanol, and the pH of the solution was adjusted to 6 with 1N hydrochloric acid. Then the solution was condensed under reduced pressure to obtain a crystalline residue. The crystalline residue thus obtained was recrystallized from methanol-ether to obtain 1-(5isoquinolinesulfonyl)homopiperazine hydrochloride. Analytical data on this compound are given below.

後処理

  1. customcondensed under reduced pressure
  2. customto obtain a crystalline residue
  3. customThe crystalline residue thus obtained
  4. customwas recrystallized from methanol-ether

出典と根拠

ORDレコード
ord-c475e692aaaf4926b344fed11d73eb97
出典データセット
uspto-grants-1987_07
特許番号
US04678783

関連ノート

読み込み中…