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Tributylvinyltin → 7-Amino-4-vinylisoindolinone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Tributylvinyltin | HCID 81998 | — |
| 反応物 | 7-Amino-4-bromo-2,3-dihydroisoindol-1-one | HCID 19701932 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 7-Amino-4-vinylisoindolinone | HCID 68488659 | 68% |
反応手順
In a similar manner to Step 1 of Example 10, 7-amino-4-bromoisoindolinone (300 mg, 1.32 mmol) was dissolved in THF (12 mL), and the solution was treated with vinyltributyltin (1.16 mL, 3.96 mmol) and bis(o-toluoylphosphine)dichloropalladium (166 mg, 0.211 mmol), followed by purification by slurry using hexane and chloroform to obtain 7-amino-4-vinylisoindolinone (155 mg, yield 68%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07745641B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-dd23c3d5e843441b888f71abd7d17ffd |
| 出典メモ | uspto-grants-2010_06 |