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Water → 1-Bromo-5-nitroisoquinoline
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Potassium Nitrate | HCID 24434 | — |
| 反応物 | Sodium Bicarbonate | HCID 516892 | — |
| 反応物 | 1-Bromoisoquinoline | HCID 640963 | — |
| 溶媒 | Sulfuric Acid | HCID 1118 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 生成物 | 1-Bromo-5-nitroisoquinoline | HCID 14617005 | — |
反応手順
The starting material was prepared by reaction of 1-bromoisoquinoline in concentrated H2SO4 at 0° with KNO3. The reaction mixture was worked up with water, NaHCO3 and EtOAc to give 1-bromo-5-nitro isoquinoline, m.p. 187°-8°. Reaction of this compound with trimethyloxonium tetrafluoroborate in CH2Cl2 gave impure 1-bromo-2-methyl-5-nitroisoquinolinium tetrafluoroborate which was used as such. n.m.r in solvent A: 3.5(s, 3H); 7.7-8.7(m, 5H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04678781 |
| 出典データセット | uspto-grants-1987_07 |
| ORD ID | ord-bfe9906dc12d4c22afc26da89b0bab9b |
| 出典メモ | uspto-grants-1987_07 |