化工社化工社 化学情報印刷レポート · 研究参考用
1-Piperazinecarboxylic acid, ethyl ester → 2-Tert-butyl-5-[4-carbethoxypiperazin-1-yl]-6-nitrobenzothiazole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-Piperazinecarboxylic acid, ethyl ester | HCID 8431 | — |
| 反応物 | 2-Tert-butyl-5-chloro-6-nitrobenzothiazole | HCID 19794202 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 2-Tert-butyl-5-[4-carbethoxypiperazin-1-yl]-6-nitrobenzothiazole | HCID 20192932 | — |
反応手順
A mixture of 3.5 g of 2-tert.-butyl-5-chloro-6-nitrobenzothiazole, described in Example 5, and 5.8 g of N-carbethoxypiperazine is heated at 180° for 2 hours, cooled and poured into water. The solid is filtered, washed with water and crystallised from isopropyl alcohol to give 2-tert-butyl-5-[4-carbethoxypiperazin-1-yl]-6-nitrobenzothiazole, melting at 100°-102°.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04680301 |
| 出典データセット | uspto-grants-1987_07 |
| ORD ID | ord-bfa4d8d9fa174f29b8406fa1c70674a3 |
| 出典メモ | uspto-grants-1987_07 |