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2-Tert-butyl-5-(4-methylpiperidin-1-yl)-6-nitrobenzothiazole → 6-Amino-2-tert-butyl-5-(4-methylpiperidin-1-yl)benzothiazole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Tert-butyl-5-(4-methylpiperidin-1-yl)-6-nitrobenzothiazole | HCID 19794189 | — |
| 触媒 | Nickel | HCID 935 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | 6-Amino-2-tert-butyl-5-(4-methylpiperidin-1-yl)benzothiazole | HCID 19794186 | — |
反応手順
A solution of 15.2 g of 2-tert-butyl-5-[4-methylpiperidin-1-yl]-6-nitrobenzothiazole in 600 ml of methanol is hydrogenated in presence of 6.5 g of raney nickel at room temperature. After removing the catalyst the solution is concentrated and the solid filtered to give 6-amino-2-tert-butyl-5-[4-methylpiperidin-1-yl]benzothiazole melting at 146°-148°.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04680301 |
| 出典データセット | uspto-grants-1987_07 |
| ORD ID | ord-0c52bcae42524bf7a8e399ce69974129 |
| 出典メモ | uspto-grants-1987_07 |