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Potassium Carbonate → 2-(4-Methyl-1-piperidinyl)-5-nitro-4'-chlorobenzophenone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 4-Methylpiperidine | HCID 69381 | — |
| 反応物 | (2-Chloro-5-nitro-phenyl)-(4-chloro-phenyl)-methanone | HCID 875720 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 2-(4-Methyl-1-piperidinyl)-5-nitro-4'-chlorobenzophenone | HCID 13105502 | 71.7% |
反応手順
A mixture of 0.07 mole (20.7 g) of 2,4'-dichloro-5-nitrobenzophenone, 0.1 mole (11.4 ml) of 4-methyl-piperidine and 10 g of K2CO3 in 100 ml of anhydrous ethanol is heated for 3 hours to reflux. After cooling of the reaction medium, the resulting precipitate is filtered, washed in water, dried then re-crystallized in ethanol. 18 g (yield: 71.7%) of the expected product are thus obtained. M.P. 136° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04680402 |
| 出典データセット | uspto-grants-1987_07 |
| ORD ID | ord-3015d8c783bd48138499226ae339aa4f |
| 出典メモ | uspto-grants-1987_07 |