2,3-Dihydro-1H-indole-7-sulfonamide → 1H-Indole-7-sulfonamide

HRID 2119115ノート

反応式

HRID 2119115 の反応式
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][C:8]=2[S:10]([NH2:13])(=[O:12])=[O:11])[CH2:3][CH2:2]1>C(Cl)Cl.[O-2].[O-2].[Mn+4]>[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][C:8]=2[S:10]([NH2:13])(=[O:11])=[O:12])[CH:3]=[CH:2]1

参加物

4

反応物 1

HCID 143467542,3-Dihydro-1H-indole-7-sulfonamide

生成物 1

HCID 143467551H-Indole-7-sulfonamide

試薬・触媒・溶媒 2

HCID 178418406HCID 178418406、化合物触媒HCID 6344Dichloromethane溶媒

反応条件

温度
25 °C

実験手順

To a slurry of activated manganese dioxide (20 g) in methylene chloride (200 ml) was added indoline-7-sulfonamide (4.3 g). The mixture was stirred at 25° C. for 24 hours. The solid was removed by filtration and the filtrate concentrated and hexane added until crystallization occurred. The pure product (TLC) was isolated by filtration (2.9 g, m.p. 125°-127° C.

後処理

  1. customThe solid was removed by filtration
  2. concentrationthe filtrate concentrated
  3. additionhexane added until crystallization
  4. customThe pure product (TLC) was isolated by filtration (2.9 g, m.p. 125°-127° C.

出典と根拠

ORDレコード
ord-97079f0cbe764a9fb79556c108c8b21d
出典データセット
uspto-grants-1987_07
特許番号
US04683000

反応ノート

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