HCID 20191014、化合物 → HCID 20191013、化合物
反応式
[OH:1][CH:2]([CH2:9][CH2:10][N:11]1[CH:15]=[CH:14][C:13]([N+:16]([O-])=O)=[N:12]1)[CH2:3][C:4]([O:6][CH2:7][CH3:8])=[O:5]>CO.[Pd].[C]>[OH:1][CH:2]([CH2:9][CH2:10][N:11]1[CH:15]=[CH:14][C:13]([NH2:16])=[N:12]1)[CH2:3][C:4]([O:6][CH2:7][CH3:8])=[O:5]参加物
4
実験手順
A solution of the above crude ethyl 3-hydroxy-5-(3-nitropyrazol-1-yl)valerate (2.41 g.) in MeOH (250 ml.) was hydrogenated over 5% w/w Pd/carbon (0.3 g.) at atmospheric pressure over 2 hours. Uptake was 650 ml. The catalyst was filtered off and the filtrate was evaporated in vacuo to give ethyl 3-hydroxy-5-(3-aminopyrazol-1-yl)valerate as an oil (1.47 g.).
後処理
- filtrationThe catalyst was filtered off
- customthe filtrate was evaporated in vacuo
出典と根拠
- ORDレコード
- ord-00114f9bf32b4659a7059ae08b98bb83
- 出典データセット
- uspto-grants-1987_07
- 特許番号
- US04683228
反応ノート
読み込み中…