Hydrochloric Acid → 2-(2-Chloroethyl)piperidine--hydrogen chloride (1/1)
反応式
O[CH2:2][CH2:3][CH:4]1[CH2:9][CH2:8][CH2:7][CH2:6][NH:5]1.[ClH:10]>>[ClH:10].[Cl:10][CH2:2][CH2:3][CH:4]1[CH2:9][CH2:8][CH2:7][CH2:6][NH:5]1参加物
3
実験手順
A 27.2 g (0.2 mole) sample of 2-(2-hydroxyethyl)piperidine was treated with ethereal hydrogen chloride and the salt was dried briefly. The solid was dissolved in 125 mL of warm chloroform and then 33.5 mL (0.46) of thionyl chloride was added in portions to the solution. The mixture was refluxed for 2.5 hr. The reaction mixture was cooled to room temperature, and the solvent evaporated in vacuo to a brown solid. The solid was recrystallized from ethanol-ether to give 17 g (46% yield) of the title compound as solid, mp=160°-162° C.
後処理
- customthe salt was dried briefly
- dissolutionThe solid was dissolved in 125 mL of warm chloroform
- addition33.5 mL (0.46) of thionyl chloride was added in portions to the solution
- temperatureThe mixture was refluxed for 2.5 hr
- customthe solvent evaporated in vacuo to a brown solid
- customThe solid was recrystallized from ethanol-ether
出典と根拠
- ORDレコード
- ord-e1860fa00b104be2bf3a6566ba3bcca4
- 出典データセット
- uspto-grants-1987_07
- 特許番号
- US04683239
反応ノート
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