Diethylamine → 2,2,2-TRIFLUOROET AMINE,N,N-DIET
反応式
[CH2:1]([NH:3][CH2:4][CH3:5])[CH3:2].C(=O)([O-])[O-].[K+].[K+].[F:12][C:13]([F:24])([F:23])[CH2:14]OS(C(F)(F)F)(=O)=O>O>[CH2:1]([N:3]([CH2:4][CH3:5])[CH2:14][C:13]([F:24])([F:23])[F:12])[CH3:2]参加物
5
実験手順
Diethyl 2,2,2-trifluoroethylamine was prepared as follows. Into a flask were placed diethylamine (5.5 g) and potassium carbonate (10.0 g). 2,2,2-Trifluoroethyl-trifluoromethanesulfonate (12 g) was slowly added to the flask. Heat was evolved. After addition, the reaction mixture was stirred at room temperature overnight. Approximately 100 mL of water was added and the organic layer was separated and dried over MgSO4. The organic liquid was distilled to receive a fraction (a clear liquid 7.25 g) at 88-89° C. under normal pressure. The clear liquid was sampled and analyzed by 1H and 19F NMR. 1H NMR: δ3.56 (q, 2H, J=9 Hz), 2.65 (q, 2H, J=7 Hz), 1.10 (t, 3H, J=7H); ·F NMR: δ−68.13 (t, 3F, J=9 Hz).