Ethanol → HCID 15839201、化合物

HRID 2119428ノート

反応式

HRID 2119428 の反応式
[OH:1][CH:2]([C:6]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[CH3:7])[C:3](N)=[O:4].[CH2:20]([OH:22])[CH3:21]>O>[OH:1][CH:2]([C:6]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[CH3:7])[C:3]([O:22][CH2:20][CH3:21])=[O:4]

参加物

4

反応物 2

HCID 702EthanolHCID 15839202HCID 15839202、化合物

生成物 1

HCID 15839201HCID 15839201、化合物

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

2.15 g (8.4 mmol) of 2-hydroxy-3,3-diphenylbutyramide were dissolved in 15 ml of ethanol, 15 ml of conc. HCI were added and the mixture was refluxed for 40 hours. The solvent was stripped off under reduced pressure, and the residue was taken up in water. The aqueous phase was extracted three times with ethyl acetate, and the combined organic phases were washed twice with 10% strength sodium hydroxide solution. Drying with MgSO4 and stripping off the solvent under reduced pressure resulted in 1.75 g (73%) of ethyl 2-hydroxy-3,3-diphenylbutyrate.

後処理

  1. addition15 ml of conc. HCI were added
  2. temperaturethe mixture was refluxed for 40 hours
  3. extractionThe aqueous phase was extracted three times with ethyl acetate
  4. washthe combined organic phases were washed twice with 10% strength sodium hydroxide solution
  5. dry with materialDrying with MgSO4
  6. customresulted in 1.75 g (73%) of ethyl 2-hydroxy-3,3-diphenylbutyrate

出典と根拠

ORDレコード
ord-814c512e81664f438b7093d9be2d38d5
出典データセット
uspto-grants-2004_02
特許番号
US06686369B1

反応ノート

読み込み中…