Propanimidamide, 2,2-dimethyl-, hydrochloride (1:1) → 10-Chloro-2-(1,1-dimethylethyl)-5,7-dihydro-6h-pyrimido[5,4-d][1]benzazepin-6-one

HRID 2119962ノート

反応式

HRID 2119962 の反応式
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[NH:11][C:10](=[O:12])[CH2:9][C:8](=[CH:13]N(C)C)[C:7](=O)[C:6]=2[CH:18]=1.Cl.[CH3:20][C:21]([CH3:26])([CH3:25])[C:22]([NH2:24])=[NH:23]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[NH:11][C:10](=[O:12])[CH2:9][C:8]3[CH:13]=[N:23][C:22]([C:21]([CH3:26])([CH3:25])[CH3:20])=[N:24][C:7]=3[C:6]=2[CH:18]=1

参加物

3

反応物 2

HCID 2781880Propanimidamide, 2,2-dimethyl-, hydrochloride (1:1)HCID 669347277-chloro-4-dimethylaminomethylene-3,4-dihydro-1H-benzo[b]azepine-2,5-dione

生成物 1

HCID 2344092810-Chloro-2-(1,1-dimethylethyl)-5,7-dihydro-6h-pyrimido[5,4-d][1]benzazepin-6-one収率 88%

実験手順

Analogous to Scheme 1, from 7-chloro-4-[(dimethylamino)methylene]-3,4-dihydro-1H-benzazepine-2,5-dione and 2,2-dimethylpropionamidine hydrochloride. Yield: 88%. Off-white solid, m/z (ISP) 302 (MH)

出典と根拠

ORDレコード
ord-9bab0709aa354225ba8bd966e388db17
出典データセット
uspto-grants-2004_02
特許番号
US06686352B2

反応ノート

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