2-(4-Methoxyphenyl)ethanimidamide hydrochloride → 10-Chloro-5,7-dihydro-2-[(4-methoxyphenyl)methyl]-6h-pyrimido[5,4-d][1]benzazepin-6-one

HRID 2119963ノート

反応式

HRID 2119963 の反応式
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[NH:11][C:10](=[O:12])[CH2:9][C:8](=[CH:13]N(C)C)[C:7](=O)[C:6]=2[CH:18]=1.Cl.[CH3:20][O:21][C:22]1[CH:27]=[CH:26][C:25]([CH2:28][C:29]([NH2:31])=[NH:30])=[CH:24][CH:23]=1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[NH:11][C:10](=[O:12])[CH2:9][C:8]3[CH:13]=[N:30][C:29]([CH2:28][C:25]4[CH:24]=[CH:23][C:22]([O:21][CH3:20])=[CH:27][CH:26]=4)=[N:31][C:7]=3[C:6]=2[CH:18]=1

参加物

3

反応物 2

HCID 122033942-(4-Methoxyphenyl)ethanimidamide hydrochlorideHCID 669347277-chloro-4-dimethylaminomethylene-3,4-dihydro-1H-benzo[b]azepine-2,5-dione

生成物 1

HCID 2344095510-Chloro-5,7-dihydro-2-[(4-methoxyphenyl)methyl]-6h-pyrimido[5,4-d][1]benzazepin-6-one収率 87%

実験手順

Analogous to Scheme 1, from 7-chloro-4-[(dimethylamino)methylene]-3,4-dihydro-1H-benzazepine-2,5-dione and 2-(4-methoxyphenyl)-acetamidine hydrochloride. Yield: 87%. White solid, m/z (ISP) 366 (MH).

出典と根拠

ORDレコード
ord-6d0ed696cb454fa3b6b1c1ab67557ebb
出典データセット
uspto-grants-2004_02
特許番号
US06686352B2

反応ノート

読み込み中…